Design and Development of Integrated Sensor for Chemical Agent Detection
| Category | Publications |
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| Abstract | Recent advances in nanotechnology promise considerable and realistic potential for the development of innovative and high performance sensing and diagnostic approaches in biomedical field. In particular, the microcantilever detection paradigm based on direct transduction of molecular binding induced surface stress into a nanomechanical motion of microcantilevers, has attracted considerable attention for label-free detection of biomolecules. As an alternative to the currently deployed optical, piezoresistive, and capacitance nanomechanical detection techniques, we introduce a new electronic transduction paradigm comprising two-dimensional microcantilever arrays with geometrically configured metal-oxide-semiconductor-field-effect-transistors (MOSFETs) embedded in the high stress region of the microcantilevers. We have shown that the deflection of the microcantilever induced by specific ligand-analyte binding events leads to a precise, measurable and reproducible change in the drain current of the MOSFET buried in the microcantilevers. High current sensitivity of MOSFET-embedded platform enables detecting nanoscale cantilever deflection from specific biomolecular binding events at very low concentration of analytes with sensitivity in the parts-per-trillion (ppt) range. We have shown ultra-sensitive detection of streptavidin-biotin based biomolecular interactions, atrazine antibody-antigen detection and biomarkers for cardiovascular diseases. This novel detection mechanism offers an excellent platform for variety of biomolecular sensing applications, from clinical diagnostics and environmental monitoring to drug discovery. |
| Contributor | Mourad Ouzzani
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| Bio | Gajendra Shekhawat received the M.S. degree in Physics from the ML Sukhadia University in India in 1991. He received his Ph.D. degree in Physics and Material Science from University of rajasthan and Central Electronic Engineering research Institute (CEERI)-India in 1996. He joined CEERI as research scientist in 1996 working on semiconducting and superconducting devices . He worked over there and developed many MEMS and CMOS based devices and ASICs. He was a research scientist at State University of New york, Albany for 3 years and developed expertise in ultrasound microscopes as well as MEMS based devices. Since 2003, he has been an research Assistant Professor at Northwestern university and manger of the Nanoscale Integrated Fabrication and Instrumentation facility at NU, where he developed several innovative technologies sucs as microcantilever based detection technologies, molecular sensors using peptide based receptors and Ultrasound holography for sub-surface nano-metrology.
Vinayak P Dravid received his Bachelor of Technology (B.Tech.) in Metallurgical Engineering in 1984 from IIT Bombay, INDIA. He was awarded his PhD in Material Science and Engineering in 1990 from Lehigh University, after which he gathered his courage and ventured into academics, right away, at Northwestern University. Vinayak is now a professor of Materials Science & Engineering, and directs a multiple facility center called: NUANCE (NU Atomic- and Nanoscale Characterization Experimental) Center. Vinayak's teaching and research interests revolve around nanoscale phenomena in materials. He is a member or an executive officer at several world-renowned NU research centers such as: International Institute for Nanotechnology (IIN), Nanoscale Science and Engineering Center (NSEC), Materials Research Center (MRC), Center for Cancer Nanotechnology Excellence (CCNE), Center for Catalysis and Surface Science (CCSS), Institute for Environmental Catalysis (IEC). |
| Cite this work | Researchers should cite this work as follows: Vinayak Dravid and Gajendra Shekhawat, "Design and Development of Integrated Sensor for Chemical Agent Detection", Trip report presented at the NSF IREE 2008 Grantees Conference, May 2008, Washington, D.C. |
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