Rational Design of Biodegradable Polymer Particles Using Carbon Dioxide
| Category | Publications |
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| Abstract | Through a collaboration between the University of Delaware Chemical Engineering Department and the University of Nottingham Schools of Chemistry and Pharmacy, the viscosities of biodegradable polymers saturated with high pressure carbon dioxide were measured experimentally. At comparable levels of free volume (as estimated from the Sanchez-Lacombe equation of state), a low molecular weight amorphous copolymer of lactic and glycolic acid (PLGA) exhibited a viscosity more than an order of magnitude higher than that of higher molecular weight semicrystalline polymers poly(caprolactone) and poly(ethylene glycol). This is believed to account for the relative difficulty in processing PLGA into fine particles for drug delivery applications. |
| Contributor | Mourad Ouzzani
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| Bio | Annette D. Shine received bachelor degrees from Washington University in St. Louis in 1976. She received her M.S. degree in Macromolecular Science from Case Western Reserve University in 1979 and a Ph.D. degree in Chemical Engineering from MIT in 1983. Following three years at Eastman Kodak, she had held academic positions at the Colorado School of Mines and the University of Delaware, where she is currently an Associate Professor of Chemical Engineering. She is a registered professional engineer, and serves on the governing council of the Delaware Association of Professional Engineers, the state licensing board.
Robert D. Bleecher received the BChE in Chemical Engineering from the University of Delaware in 2008. He is currently employed as a process engineer at Coskata, Inc. in Warrenville, IL. |
| Sponsored By | NSF Award Number 0553659 |
| Cite this work | Researchers should cite this work as follows: ANNETTE D. SHINE and ROBERT D. BLEECHER, "Rational Design of Biodegradable Polymer Particles Using Carbon Dioxide", Trip report presented at the NSF IREE 2008 Grantees Conference, May 2008, Washington, D.C. |
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