Poly(N-vinyl-2-pyrrolidone)-coated magnetite nanoparticles were incorporated within a layer-by-layer (LbL) film also containing more traditional LbL components, including DNA and a polycationic component produced by crosslinking putrescine with bioreducible dimethyl 3,3´-dithiobispropionimidate (DTBP). This created a film with multiple potential functions, as polycation/DNA LbL films are often constructed for gene delivery studies and antibody-conjugated magnetite nanoparticles have successfully been used for magnetic resonance imaging-based cancer detection in mice. This work performed at the Institute of Chemistry, Chinese Academy of Sciences in Beijing is a first step toward developing a multifuctional therapeutic device that could be used to treat cancer as well as track the treatment progress.

Poly(N-vinyl-2-pyrrolidone)-coated magnetite nanoparticles were incorporated within a layer-by-layer (LbL) film also containing more traditional LbL components, including DNA and a polycationic component produced by crosslinking putrescine with bioreducible dimethyl 3,3´-dithiobispropionimidate (DTBP). This created a film with multiple potential functions, as polycation/DNA LbL films are often constructed for gene delivery studies and antibody-conjugated magnetite nanoparticles have successfully been used for magnetic resonance imaging-based cancer detection in mice. This work performed at the Institute of Chemistry, Chinese Academy of Sciences in Beijing is a first step toward developing a multifuctional therapeutic device that could be used to treat cancer as well as track the treatment progress.

Researchers should cite this work as follows:

• Kyle Alexander Sutton (2010), "Magnetic Nanoparticles in Polymer/DNA Layer-by-Layer Films: A Proof of Concept Study," http://globalhub.org/resources/4123.

1. China 90
2. iree 2010 76